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phenobarbital will decrease the level or influence of rabeprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unfamiliar.phenobarbital will lower the extent or effect of ketoconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.phenobarbital will lessen th